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Essentially, L-DOPA is transported across the blood brain barrier by LAT-1 (L or Large amino acid transporter). This transporter moves amino acids like phenylalanine and tyrosine across the blood brain barrier. Without a transporter, a molecule needs to be lipid soluble to cross the blood brain barrier.
Use Sinemet Cr exactly as prescribed by your doctor. Do not take more of this drug than is recommended. Take this medication with a full glass of water with or without food at the same time every day. Your doctor may occasionally change your dose to make sure you get the best results from this medication.
Generic Sinemet (carbidopa and levodopa) is a treatment for symptoms of Parkinson’s Disease. Generic Sinemet is one of Merck Sharp & Dohme’s best-selling drugs mainly prescribed to treat Parkinson’s symptoms & countless off-label uses. Generic Sinemet is a cost-saving medication prescribed by medical physicians worldwide! Generic Sinemet is also marketed as Parcopa, Atamet, Apo-Levocarb, Carbidopa and levodopa. *Sinemet® is manufactured by Merck Sharp & Dohme Corporation.
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Unfortunately, it can cause side effects, like nausea, vomiting, sleepiness, and low blood pressure. If you take levodopa over a long period of time, you may experience involuntary twisting or writhing movements (dyskinesia), and possibly psychotic delusions or hallucinations
When carbidopa and levodopa are administered together, the half-life of levodopa is increased to about 1.5 hours. At steady state, the bioavailability of carbidopa from SINEMET tablets is approximately 99% relative to the concomitant administration of carbidopa and levodopa.

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