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Directions. Read the Patient Information Leaflet provided by your pharmacist before you start using sorafenib. Take this medication by mouth on an empty stomach (at least 1 hour before or 2 hours after a meal) as directed by your doctor, usually twice a day. Do not chew or crush the tablets. Swallow tablets whole with a full glass of water.
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General information. Nexavar is a cancer medication that interferes with the growth and spread of cancer cells in the body. Sorafenib stops or slows the growth of cancer cells (tumors). It also works by slowing the growth of new blood vessels within the tumor. Nexavar may also be used to treat a certain type of thyroid cancer (differentiated thyroid carcinoma).
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Possible side effect. The most common side effects are acne, dry skin, nausea, diarrhea, patchy hair loss/thinning, loss of appetite, dry mouth, hoarseness, or tiredness may occur. Notify your doctor if these effects persist or worsen. Serious side aeffects are bone/muscle pain, depression, easy bruising or bleeding, headache, tongue/mouth sores or pain, numbness/tingling of the hands/feet, shortness of breath, swollen hands/ankles/feet, signs of liver problems such as stomach/abdominal pain, persistent nausea/vomiting, yellowing eyes/skin, dark urine. Check your blood pressure regularly as this medication may raise it. This medication can affect how your thyroid works. Tell your doctor right away if you have signs of an underactive thyroid such as weight gain, cold intolerance, slow heartbeat, constipation, or unusual tiredness or signs of an overactive thyroid such as mental/mood changes, heat intolerance, fast/pounding/irregular heartbeat or unusual weight loss. Contact your doctor right away if you notice skin problems (such as rash, blisters, redness, swelling, pain), especially on the palms of your hands or the soles of your feet.
Contraindications. Before taking sorafenib, tell your doctor or pharmacist if you are allergic to it. You should not use Nexavar if you have squamous cell lung cancer and you are being treated with carboplatin (Paraplatin) and paclitaxel (Onxol, Taxol, Abraxane). Do not use Nexavar if you have kidney or liver problems other than cancer; lung cancer; a bleeding or blood clotting disorder such as hemophilia; high blood pressure (hypertension), heart disease, slow heartbeats, congestive heart failure, chest pain; a personal or family history of Long QT syndrome; a history of stroke or heart attack.

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