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The diuretic spironolactone can cause dangerous hyperkalaemia in patients who are also taking angiotensin converting enzyme (ACE) inhibitors, another drug that, like spironolactone, is used to treat congestive heart failure.
Mechanism Of Action. ALDACTONE (spironolactone) is a specific pharmacologic antagonist of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule.
Drinking alcohol can increase certain side effects of spironolactone. Do not use salt substitutes or low-sodium milk products that contain potassium. These products could cause your potassium levels to get too high while you are taking spironolactone.
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No, Spironolactone is an aldosterone blocking agent blocking the effects of the adrenal hormone Aldosterone that is part of the renin angiotensin system, inducing water and salt retention, thus causing water overload and maybe high blood pressure
BRAND NAME: Aldactone. USES: Aldactone removes excess fluid from the body in congestive heart failure, cirrhosis of the liver, and kidney disease. It also can be used in combination with other drugs to treat elevated blood pressure, and for treating diuretic-induced low potassium (hypokalemia).

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