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July 26, 2018 at 12:10 am #43430
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What is the risk associated with Forxiga? The most common side effect with Forxiga (seen in more than 1 patient in 10) is hypoglycaemia when used with a sulphonylurea or insulin. For the full list of side effects reported with Forxiga, see the package leaflet. Forxiga must not be used in people who are hypersensitive (allergic) to dapagliflozin or any of the other ingredients.
The most common side effects are hypoglycemia, thrush, urinary tract infections, increased need to visit the toilet, pain when urinating, changes in levels of blood fats, lowering of blood pressure. Check with your doctor as soon as possible if any of the following side effects occur: redness or rash of the penis or foreskin (yeast infection), signs of dehydration (e.g., decreased urine, dry skin, dry and sticky mouth, sleepiness, dizziness, headache, thirst, confusion), signs of vaginal yeast infection (e.g., vaginal odour, curd-like discharge, itching), symptoms of low blood sugar (e.g., cold sweat, cool pale skin, headache, fast heartbeat, weakness, blurred vision), symptoms of a urinary tract infection (e.g. pain when urinating, urinating more often than usual, low back or flank pain, strong odour). Stop taking the medication and seek immediate medical attention if any of the following occur: fainting or lightheadedness when standing, severe dehydration (e.g., confusion, sweating stops, heart palpitations), severe hypoglycemia (low blood sugar; disorientation, loss of consciousness, seizure), signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat).
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In all of the studies, the main measure of effectiveness was the level of a substance in the blood called glycosylated haemoglobin (HbA1c), which gives an indication of how well the blood glucose is controlled. What benefit has Forxiga shown during the studies? Forxiga was more effective than placebo at reducing the levels of HbA1c when used alone and in combination with other antidiabetes medicines. When Forxiga was used on its own at a dose of 10 mg, it decreased HbA1c levels by 0.66% more than placebo after 24 weeks. When Forxiga was added to other antidiabetes medicines, Forxiga 10 mg decreased HbA1c levels by 0.54-0.68% more than placebo after 24 weeks. When compared with a sulphonylurea, Forxiga was at least as effective and both medicines reduced HbA1c levels by 0.52% after 52 weeks. -
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