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Check with your doctor as soon as possible if any of the following side effects occur: redness or rash of the penis or foreskin (yeast infection) signs of dehydration (e.g., decreased urine, dry skin, dry and sticky mouth, sleepiness, dizziness, headache, thirst, onfusion) signs of vaginal yeast infection (e.g., vaginal odour, curd-like discharge, itching)
The recommended starting dose for dapagliflozin is 5 mg taken by mouth once a day. Your doctor may adjust the dose up to a maximum 10 mg daily, depending on how effective it is and how well it is tolerated. Dapagliflozin should be taken at the same time every day. The tablets should be swallowed whole with some water and may be taken with food or on an empty stomach. Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health.
Possible Side Effects Side effects of Forxiga may include: Hypoglycemia –if taken with sulphonylureas or insulin Thrush Urinary tract infections Increased need to visit the toilet (polyuria) Pain when urinating Changes in levels of blood fats Lowering of blood pressure
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How has Forxiga been studied? The effects of Forxiga were first tested in experimental models before being studied in humans. Forxiga on its own has been compared with placebo (a dummy treatment) in two studies in 840 patients. A third study compared Forxiga with a sulphonylurea (glipizide), both taken in combination with metformin in 814 patients. Four other studies compared Forxiga with placebo, when used as an add-on to either metformin, a sulphonylurea (glimepiride), a thiazolidinedione or insulin in 2,370 patients.
Commonly seen side effects were related to the way the medicine works, such as increased genital and, to a smaller degree, urinary-tract infection (infection of the structures that carry urine), and are considered to be manageable. A small but higher number of bladder-, breast- and prostate-cancer cases were seen in patients who took Forxiga compared with patients who took placebo. However, there was no difference between the groups when cancer overall was considered and preclinical studies investigating the risk of developing cancer with Forxiga did not show this risk. -
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