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VIAGRA (50 mg) did not potentiate the hypotensive effect of alcohol (0.5 g/kg) in healthy volunteers with mean maximum blood alcohol levels of 0.08%. The maximum observed decrease in systolic blood pressure was -18.5 mmHg when viagra was co-administered with alcohol versus -17.4 mmHg when alcohol was administered alone. The maximum observed decrease in diastolic blood pressure was -17.2 mmHg when viagra was co-administered with alcohol versus -11.1 mmHg when alcohol was administered alone. There were no reports of postural dizziness or orthostatic hypotension. The maximum recommended dose of 100 mg viagra was not evaluated in this study [see DRUG INTERACTIONS].
viagra enhances the effect of NO by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. viagra has no direct relaxant effect on isolated human corpus cavernosum. When sexual stimulation causes local release of NO, inhibition of PDE5 by viagra causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. viagra at recommended doses has no effect in the absence of sexual stimulation.
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In clinical trials, the most common adverse effects of viagra use included headache, flushing, indigestion, nasal congestion, and impaired vision, including photophobia and blurred vision.[2] Some viagra users have complained of seeing everything tinted blue (cyanopsia).[10] Some complained of blurriness and loss of peripheral vision. In July 2005, the FDA found that viagra could lead to vision impairment in rare cases[11] and a number of studies have linked viagra use with non-arteritic anterior ischemic optic neuropathy.[12]
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