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The active substance in Forxiga, dapagliflozin, works by blocking a protein in the kidneys called sodium‑glucose co‑transporter 2 (SGLT2). SGLT2 is a protein that absorbs glucose from the urine into the bloodstream as the blood is filtered in the kidneys. By blocking the action of SGLT2, Forxiga causes more glucose to be removed via the urine, thereby reducing the levels of glucose in the blood.
What is the risk associated with Forxiga? The most common side effect with Forxiga (seen in more than 1 patient in 10) is hypoglycaemia when used with a sulphonylurea or insulin. For the full list of side effects reported with Forxiga, see the package leaflet. Forxiga must not be used in people who are hypersensitive (allergic) to dapagliflozin or any of the other ingredients.
Dapagliflozin is not suitable for people who have type 1 diabetes, have low kidney function, are galactose intolerant, have low salt levels in their body, are under the age of 18 or over the age 75, people on a course of Actos (pioglitazone) or loop diuretics.
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How has Forxiga been studied? The effects of Forxiga were first tested in experimental models before being studied in humans. Forxiga on its own has been compared with placebo (a dummy treatment) in two studies in 840 patients. A third study compared Forxiga with a sulphonylurea (glipizide), both taken in combination with metformin in 814 patients. Four other studies compared Forxiga with placebo, when used as an add-on to either metformin, a sulphonylurea (glimepiride), a thiazolidinedione or insulin in 2,370 patients.
Before using Victoza You should not use Victoza if you are allergic to liraglutide, or if you have: multiple endocrine neoplasia type 2 (tumors in your glands); a personal or family history of medullary thyroid carcinoma (a type of thyroid cancer); or diabetic ketoacidosis (call your doctor for treatment).
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