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Notify you doctor about a list of additional medicines or supplements you are already taking besides this one. It is not advisable to combine the usage of this product with other drugs of similar class without your doctor’s permission. It has been reported that Sinemet interacts with a class of antidepressants used to treat depression such as monoamine oxidase inhibitors: Phenelzine (Nardil, Nardelzine), Tranylcypromine (Parnate, Jatrosom), Isocarboxazid (Marplan), Selegiline (Deprenyl, Eldepryl, Emsam); with remedies that contain iron.
The active ingredient in Generic Sinemet, Levodopa is converted to dopamine via the action of a naturally occurring enzyme called DOPA decarboxylase. This occurs both in the peripheral circulation and in the central nervous system after levodopa has crossed the blood brain barrier. Activation of central dopamine receptors improves the symptoms of Parkinson’s disease.
If you are taking any of these drugs: Reserpine or tetrabenazine. If you have taken certain drugs used for low mood (depression) like isocarboxazid, phenelzine, or tranylcypromine or drugs used for Parkinson’s disease like selegiline or rasagiline in the last 14 days. Taking this medicine within 14 days of those drugs can cause very bad high blood pressure. If you are taking another drug that has the same drug in it. This is not a list of all drugs or health problems that interact with Sinemet.
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