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Hyponatremia is an uncommon, but serious, complication of diuretic therapy. Thiazide diuretics are more likely than loop diuretics to cause hyponatremia. Loop diuretics inhibit sodium (Na+) transport in the renal medulla and prevent the generation of a maximal osmotic gradient.
Take spironolactone exactly as your doctor has told you. The usual dose varies from 25 mg to 200 mg. Depending upon which dose is right for you, you may be asked to take several tablets a day but these are generally taken at the same time. Take the tablets with or just after a meal.
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According to the low effective arterial volume and the extrarenal loss of sodium, aldosterone secretion increased. … However, during episodes of intestinal loss of sodium the spironolactone-induced impairment of aldosterone-mediated resorption of sodium can cause a life-threatening hyponatremia. -
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