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Time to peak plasma concentration is approximately one hour. Distribution � Although the plasma half life of spironolactone itself is short (1.3 hours) the half lives of the active metabolites are longer (ranging from 2.8 to 11.2 hours). Spironolactone is estimated to be 90% protein bound.
Hyponatremia is an uncommon, but serious, complication of diuretic therapy. Thiazide diuretics are more likely than loop diuretics to cause hyponatremia. Loop diuretics inhibit sodium (Na+) transport in the renal medulla and prevent the generation of a maximal osmotic gradient.
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Spironolactone is usually well tolerated, but just as with any medication, side effects are possible. Common side effects include irregular menses, midcycle spotting, breast tenderness, and headaches. Very rarely, Spironolactone can cause a rash, liver, kidney or blood problems.