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Common side effects include: breast pain or tenderness; headache; hair loss; spotting or breakthrough bleeding; mild nausea or vomiting;stomach cramps or bloating. Serious side effects are allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); back pain;breast discharge or lump in the breast; calf or leg pain or swelling; chest pain; coughing up blood; dark urine; depression; dizziness; fainting; fever; memory problems; mental or mood changes; muscle pain; one-sided weakness; painful or difficult urination; persistent or severe breast pain or tenderness; persistent or severe headache, nausea, or vomiting; severe stomach pain or swelling; slurred speech; sudden shortness of breath; sunburn-like rash; swelling of hands, legs, or feet; unusual vaginal bleeding, discharge, itching, or odor; vision changes; vomiting; weakness or numbness of an arm or leg; yellowing of the skin or eyes.
Common side effects may include: light vaginal bleeding or spotting; nausea, vomiting, stomach pain; headache; vaginal itching or discharge; breast pain; or. swelling, bloating, weight gain.
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Estrace belongs to the class of medications named estrogen replacement therapy. Estrogen is a hormone produced by the ovaries, specific estrogen-receptors are located in different organs (in the uterus, vagina, urethra, mammary glands, liver, hypothalamus, pituitary) and stimulates development and growth of female sex organs starting from puberty: uterus, fallopian tubes, vagina, stroma and ducts of mammary glands, pigmentation of nipples and genitals, formation of secondary sexual characteristics of female type, formation of epiphyses of long bones. Estrogen is responsible for the timely and regular rejection of the endometrium and bleeding, in high concentrations estrogen causes endometrial hyperplasia, suppresses lactation, inhibits bone resorption. Estrace is used to treat menopause symptoms which include hot flashes, and vaginal dryness, burning, and irritation. It is also used for treatment of cancer in women and men and osteoporosis.
Estrogen can inhibit the metabolism of cyclosporine resulting in increase of its levels in blood and kidney and/or liver damage. Estrogen are abler to increase the risk of liver disease in patients treated by dantrolene. Known to affect a clot formation Estrace should be used carefully together with warfarin (Coumadin). Enhanced metabolism and excretion of Estrace may be stipulated by rifampin, barbiturates, carbamazepine (Tegretol), griseofulvin, phenytoin (Dilantin) and primidone. -
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