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Possible Side Effects Side effects of Forxiga may include: Hypoglycemia –if taken with sulphonylureas or insulin Thrush Urinary tract infections Increased need to visit the toilet (polyuria) Pain when urinating Changes in levels of blood fats Lowering of blood pressure
severe dehydration (e.g., confusion, sweating stops, heart palpitations) severe hypoglycemia (low blood sugar; disorientation, loss of consciousness, seizure) signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
Forxiga is indicated in adults aged 18 years and older with type-2 diabetes mellitus to improve glycaemic control as: monotherapy when diet and exercise alone do not provide adequate glycaemic control in patients for whom use of metformin is considered inappropriate due to intolerance; add-on combination therapy in combination with other glucose-lowering medicinal products including insulin, when these, together with diet and exercise, do not provide adequate glycaemic control.
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In all of the studies, the main measure of effectiveness was the level of a substance in the blood called glycosylated haemoglobin (HbA1c), which gives an indication of how well the blood glucose is controlled. What benefit has Forxiga shown during the studies? Forxiga was more effective than placebo at reducing the levels of HbA1c when used alone and in combination with other antidiabetes medicines. When Forxiga was used on its own at a dose of 10 mg, it decreased HbA1c levels by 0.66% more than placebo after 24 weeks. When Forxiga was added to other antidiabetes medicines, Forxiga 10 mg decreased HbA1c levels by 0.54-0.68% more than placebo after 24 weeks. When compared with a sulphonylurea, Forxiga was at least as effective and both medicines reduced HbA1c levels by 0.52% after 52 weeks.