Zidovudine associated myopathy

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Zidovudine associated myopathy
Acta Neuropathol. 1995;90(1):1-6. Early features of zidovudine-associated
myopathy: histopathological findings and clinical correlations. Cupler EJ(1),
Danon …Literature is replete with studies on zidovudine-induced myopathy after
prolonged use (use beyond 270 days on an average). However, all these studies
have …Ann Neurol. 1991 Jun;29(6):606-14. Zidovudine myopathy: a distinctive disorder
associated with mitochondrial dysfunction. Mhiri C(1), Baudrimont M, Bonne G, …Abstract. Myopathy may occur as a complication of human immunodeficiency
virus type 1 (HIV) infection or from its treatment, zidovudine (ZDV). We reviewed …Initially anti retroviral therapy (ART) associated myopathy was described with
Zidovudine (ZDV). Nucleoside reverse transcriptase inhibitors (NRTIs) were
found …19 Apr 1990 … To identify criteria for distinguishing zidovudine-induced myopathy from that
caused by primary HIV infection, we reviewed the histochemical, …27 May 2008 … Mechanisms of Zidovudine-Induced Mitochondrial Toxicity and Myopathy.
Scruggs E.R. · Dirks Naylor A.J.. Author affiliations. Wingate …1 Nov 2016 … Neuromuscular conditions associated with HIV infection include the following: …
Medication-induced myopathy (e.g., zidovudine). HIV wasting …Abstract. One hundred and eighteen consecutively identified AIDS patients, 88 of
whom received zidovudine (1000–1200 mg/day), were followed for 1 year to …acteristic structural myopathy associated with mitochondrial changes in 13
patients, all of whom had received long- term zidovudine therapy. The mean …After some months of therapy, AZT was associated with a variety of common
tissue toxicities that included myopathy, dilated cardiomyopathy, hepatotoxicity, …serum CK while on zidovudine. These patients also showed vesicular changes
due to enlargement and electron lucency of mitochondria associated with disrup-.Myopathy often complicates Zidovudine (AZT) treatment in patients with acquired
immunodeficiency syndrome (AIDS). The pathogenesis of the myopathy is …Learn about Combivir (Lamivudine, Zidovudine) may treat, uses, dosage, …
Prolonged use of zidovudine has been associated with symptomatic myopathy [
see …There are numerous potential mechanisms that may contribute to AZT-induced
myopathy. The first hypothesized mechanism to explain AZT-induced toxicity was
 …indinavir, lamivudine, ritonavir, saquinavir, stavudine, zidovudine. Other
gancyclovir … lowering drug-induced myopathies by Vladutiu et al. (2006), found
four …Symptomatic myopathy associated with prolonged use of zidovudine. …. (
lamivudine and zidovudine) Tablets, has been associated with hematologic
toxicity.AZT may also cause myopathy, a weakness or loss of muscle mass, …
particularly d4T and to a lesser extent AZT, have been associated with loss of the
fatty …28 Feb 2003 … Treatment with NRTIs has been associated with mitochondrial ….. Griffin JL:
Mitochondrial myopathy caused by long-term zidovudine therapy.For this reason, zidovudine use by 49 men with AIDS-associated lymphoma ……
skeletal muscle myopathy seen in HIV-positive individuals given long-term zido-.

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