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Not to be confused with the related chemical naloxone. Naltrexone reverses the effects of opioids and is used primarily in the management of alcohol dependence and opioid dependence. It is marketed in generic form as its hydrochloride salt, naltrexone hydrochloride, and marketed under the trade names Revia and Depade.
No, you cannot get high on naltrexone. In fact, naltrexone is prescribed to treat opiate/opioid addiction and alcoholism by blocking the pleasurable and euphoric effects of these substances. It works by binding to opioid receptors in the central nervous system that these drugs normally occupy.
LDN can be taken along with any other medication or substance, so long as it is not narcotic-containing. Naltrexone is a pure opioid antagonist and it will block the action of narcotics. Some examples of narcotic-containing drugs are Ultram, morphine, Percocet, Duragesic patch and any codeine-containing medication.
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The mean elimination half-life (T-?) values for naltrexone and 6-?-naltrexol are 4 hours and 13 hours, respectively. Naltrexone and 6-?-naltrexol are dose proportional in terms of AUC and Cmax over the range of 50 to 200 mg and do not accumulate after 100 mg daily doses.
Naltrexone belongs to a class of drugs known as opiate antagonists. It works in the brain to prevent opiate effects (e.g., feelings of well-being, pain relief). It also decreases the desire to take opiates. This medication is also used to treat alcohol abuse.

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