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Directions. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended. If your headache does not completely go away, or goes away and comes back, take a second tablet 2 hours after the first. Do not take more than 80 mg of eletriptan in 24 hours. If your symptoms have not improved, contact your doctor before taking any more tablets. Call your doctor if your headache does not go away at all after taking the first Relpax tablet. Never use more than your recommended dose. Overuse of migraine headache medicine can make headaches worse. Do not take migraine headache medication for longer than 10 days in any 1 month. Tell your doctor if the medicine seems to stop working as well in treating your migraine attacks. If you use Relpax long-term, your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG). This will help your doctor determine if it is still safe for you to take Relpax.
Precautions. Certain foods, beverages, or food additives (such as red wine, cheese, chocolate, monosodium glutamate) as well as lifestyle patterns such as irregular eating/sleeping habits or stress may bring on a migraine headache. Avoiding these “triggers” may help lessen migraine attacks. Before taking Relpax, tell your doctor if you have liver or kidney disease, high blood pressure, a heart rhythm disorder, or coronary heart disease (or risk factors such as diabetes, menopause, smoking, being overweight, having high cholesterol, having a family history of coronary artery disease, being older than 40 and a man, or being a woman who has had a hysterectomy). Do not take Relpax within 24 hours before or after using another migraine headache medicine. Do not use Relpax within 72 hours before or after taking: clarithromycin, itraconazole, ketoconazole, nefazodone, ritonavir, or nelfinavir.
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Drug interactions. Avoid taking certain medications that can affect the removal of eletriptan from your body within 72 hours of taking eletriptan. Examples include cobicistat, nefazodone, azole antifungals such as ketoconazole/itraconazole, macrolide antibiotics such as clarithromycin/erythromycin, certain hepatitis C virus protease inhibitors such as boceprevir/telaprevir, HIV protease inhibitors such as nelfinavir/ritonavir, among others. If you also take any ergotamine medication (such as dihydroergotamine) or other “triptan” drugs (such as sumatriptan, rizatriptan), separate your eletriptan dose at least 24 hours apart from your dose of these other medications to lessen the chance of serious side effects. The risk of serotonin syndrome/toxicity increases if you are also taking other drugs that increase serotonin. Examples include street drugs such as MDMA/”ecstasy,” St. John’s wort, certain antidepressants (including SSRIs such as fluoxetine/paroxetine, SNRIs such as duloxetine/venlafaxine), among others. The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs.

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