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    Hydroxyurea works in two ways. The first way is in the red blood cells. Red blood cells contain hemoglobin that carries oxygen to all parts of the body. People who have sickle cell disease make an abnormal hemoglobin called sickle hemoglobin.
    In part, this happens because hydroxyurea increases the amount of fetal hemoglobin (Hb F) in red blood cells. Newborn babies have Hb F when they are born. Hb F helps protect them from sickle cell complications (health problems) during the first few months of life.
    Some medicines that treat cancer cause infertility but many in fact do not. There is not good evidence that hydroxyurea causes infertility. There is some evidence in animals that hydroxyurea can reduce sperm counts and also sickle cell disease on its own can reduce sperm counts.
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    Missed dose: Take the missed dose as soon as possible. Skip the missed dose if it is time for your next scheduled dose. Don’t take extra medicine to make up the missed dose.
    Some medicines that treat cancer cause infertility but many in fact do not. There is not good evidence that hydroxyurea causes infertility. There is some evidence in animals that hydroxyurea can reduce sperm counts and also sickle cell disease on its own can reduce sperm counts.

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