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    Hydroxyurea is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. Hydroxyurea is classified as an “antimetabolite.”
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    Hydroxyurea is used to treat chronic myelocytic leukemia, ovarian cancer, and certain types of skin cancer (melanoma and primary squamous cell cancer of the head and neck). Hydroxyurea is also used to reduce pain episodes and the need for blood transfusions in people with sickle cell anemia.
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    Some medicines that treat cancer cause infertility but many in fact do not. There is not good evidence that hydroxyurea causes infertility. There is some evidence in animals that hydroxyurea can reduce sperm counts and also sickle cell disease on its own can reduce sperm counts.
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