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Generic Lyrica (Pregabalin) Analgesics, Anticonvulsants, Neurological Disorders Lyrica (pregabalin) is an anti-epileptic drug, also called an anticonvulsant. It works by slowing down impulses in the brain that cause seizures. Lyrica also affects chemicals in the brain that send pain signals across the nervous system.Lyrica is used to control seizures and to treat fibromyalgia. It is also used to treat pain caused by nerve damage in people with diabetes (diabetic neuropathy), herpes zoster (post-herpetic neuralgia, or neuropathic pain associated with spinal cord injury. Brand(s): Prebel Manufacturer: Johnlee Pharmaceuticals Disease(s): Fibromyalgia / Diabetic Peripheral Neuropathy / Seizures Known as: Lyrica
Lyrica capsules and oral solution both contain the active ingredient pregabalin, which is a medicine that is used for three different purposes – treating epilepsy, nerve pain and anxiety. The way in which pregabalin works is not fully understood. It is thought to work by binding to calcium channels found on nerve cells in the brain and spinal cord. This reduces the release of various neurotransmitters from these nerve cells. Neurotransmitters are natural body chemicals that are stored in nerve cells. They are involved in transmitting messages between the nerve cells. Pregabalin is thought to reduce the release of neurotransmitters called glutamate, noradrenaline and substance P. Glutamate is a neurotransmitter that acts as a natural ‘nerve-exciting’ agent. It is released when electrical signals build up in nerve cells and subsequently excites more nerve cells. It is thought to play a key role in causing epileptic seizures. Reducing the release of glutamate from the nerve cells in the brain is thought to help stabilise the electrical activity in the brain and prevent epileptic fits. Pregabalin is used as an add-on treatment for adults whose epilepsy has not been well controlled by other anti-epileptic medicines. It is used to prevent partial seizures, and partial seizures that spread to secondary generalised seizures. Glutamate, substance P and noradrenaline are also involved in transmitting pain signals in the brain and nervous system. As pregabalin reduces the release of these neurotransmitters it can also be used to treat nerve pain occuring as a result of damage to or a disturbance in the function of nerves (neuropathic pain). It can be used for peripheral neuropathic pain, ie nerve pain in the hands, legs or feet, or central neuropathic pain, eg as a result of a spinal cord injury. Pregabalin can also used to treat generalised anxiety disorder, which is another condition thought to involve overactivity of glutamate, substance P and noradrenaline in the brain.
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Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine. The safety of this medicine during pregnancy has not been established. It should not be used during pregnancy unless your doctor considers that the benefits to the mother clearly outweigh any potential risks to the developing baby. Women who could get pregnant should use an effective method of contraception to prevent pregnancy while taking this medicine. Seek medical advice from your doctor. This medicine does not affect hormonal contraceptives such as the pill. It is not known if this medicine passes into breast milk. For this reason, breastfeeding is not recommended while taking this medicine. Seek medical advice from your doctor.
Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.You may have increased seizures or withdrawal symptoms such as headache, sleep problems, nausea, and diarrhea. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks. If you have a heart condition, like congestive heart failure, and notice that you are retaining water and have swelling in your hands or feet, contact your health care provider immediately.

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