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To make sure Coumadin is safe for you, tell your doctor if you have: celiac sprue (an intestinal disorder); diabetes; congestive heart failure; overactive thyroid; a connective tissue disorder such as Marfan Syndrome, Sjögren syndrome, scleroderma, rheumatoid arthritis, or lupus; a hereditary clotting deficiency (warfarin may make your symptoms worse at first); if you use a catheter; or if you have ever had low blood platelets after receiving heparin.
Before taking this medicine You should not take warfarin if you are allergic to it, or if you have: hemophilia or any bleeding disorder that is inherited or caused by disease; a blood cell disorder (such as low red blood cells or low platelets); blood in your urine or stools, or if you have been coughing up blood; an infection of the lining of your heart (bacterial endocarditis); stomach or intestinal bleeding or ulcer; very high blood pressure; recent or upcoming surgery on your brain, spine, or eye; recent head injury, aneurysm, or bleeding in the brain; or
What should I avoid while taking warfarin? Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth. You may still bleed more easily for several days after you stop taking warfarin. Avoid drinking alcohol.
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To make sure warfarin is safe for you, tell your doctor if you have: celiac sprue (an intestinal disorder); diabetes; congestive heart failure; overactive thyroid; a connective tissue disorder such as Marfan Syndrome, Sjögren syndrome, scleroderma, rheumatoid arthritis, or lupus; a hereditary clotting deficiency (warfarin may make your symptoms worse at first); if you use a catheter; or if you have ever had low blood platelets after receiving heparin. It is not known whether warfarin passes into breast milk. Tell your doctor if you are breast-feeding a baby. Watch for signs of bruising or bleeding in the baby if you take warfarin while you are nursing.
The duration of anticoagulant therapy for a first-time deep venous thrombosis is usually 3 to 12 months, depending on the reversibility of the condition which may have predisposed this patient to thrombosis. For patients with a first episode of DVT secondary to a reversible risk factor, 3 months of warfarin therapy is recommended. For patients with a first episode of idiopathic DVT, at least 6 to 12 months of treatment is recommended. For patients with two or more episodes of documented DVT, indefinite treatment with warfarin is recommended. For patients with a first episode of DVT who have documented antiphospholipid antibodies or who have two or more thrombophilic conditions, treatment for 12 months is recommended and indefinite therapy is suggested. For patients with a first episode of DVT who have documented deficiency of Protein C or Protein S, deficiency of antithrombin, or the Factor V Leiden or prothrombin 20210 gene mutation, homocystinemia, or high Factor VIII levels, treatment for 6 to 12 months is recommended and indefinite therapy is suggested for idiopathic thrombosis.

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