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Zetia (ezetimibe) is a drug used to help treat high cholesterol, and works in a different way than statins, which lower cholesterol by 35 to 60 percent in most patients and reduce the risk of heart attacks among them.Zetia is commonly used for the treatment of several conditions, including high cholesterol and a rare genetic condition called sitosterolemia. Part of a class of drugs called cholesterol absorption inhibitors, it works by blocking the absorption of cholesterol from foods that you eat.Does Zetia Work? The 2008 ENHANCE Trial sowed doubt about whether Zetia (ezetimibe) when added to Zocor (simvastatin), can prevent the bad outcomes associated with high cholesterol.Zetia works to lower cholesterol in a new way different from the statins: it inhibits the absorption of cholesterol in the small intestine, whereas the statins work by blocking cholesterol production in the liver.Zetia is the brand name for ezetimibe, a drug that lowers LDL cholesterol levels by reducing cholesterol absorption in the small intestine.. …Crestor is a statin (rosuvastatin calcium) only, Vytorin is a statin (Simvastatin) with Zetia (ezetimibe). Statins work by controlling the production of cholesterol in your liver while Zetia works by preventing cholesterol to be absorbed in your digestive system. Of the two, Crestor is the stronger of the two.Zetia is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely. Store at room temperature away from moisture and heat.